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The JUPITER trial (2008)demonstrated a 44% reduction in combined end-point of stroke, MI, unstable angina andcardiovascular death by using high potencyrosuvastatin. Modifiedbases generated by RS are highly mutagenic and can induce base-mispairing during DNAreplication, generating mutations that affect cellular physiology [7]

Modifiedbases generated by RS are highly mutagenic and can induce base-mispairing during DNAreplication, generating mutations that affect cellular physiology [7].

For example, both Hg and cd can increaseintracellular production of ROS and target mitochondriawithin the proximal tubular epithelial cell.

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